Name: Synthesis And Evaluation Of Some Aryl Propionic Acid Derivatives (en Inglés)
Price: 280594.00 COP
Availability: InStock
Author: Kumar, Punet ; Mishra, Arun K. ; Kumar, Arvind
ISBN: 9786202557078

portada Synthesis And Evaluation Of Some Aryl Propionic Acid Derivatives (en Inglés)

Formato

Libro Físico

Autor

Arvind Kumar

Punet Kumar

Arun K. Mishra

Editorial

LAP Lambert Academic Publishing

Idioma

Inglés

N° páginas

104

Encuadernación

Tapa Blanda

Dimensiones

22.9 x 15.2 x 0.6 cm

Peso

0.16 kg.

ISBN13

9786202557078

Categorías

Química

Synthesis And Evaluation Of Some Aryl Propionic Acid Derivatives (en Inglés)

Arvind Kumar (Autor) · Punet Kumar (Autor) · Arun K. Mishra (Autor) · LAP Lambert Academic Publishing · Tapa Blanda

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Reseña del libro "Synthesis And Evaluation Of Some Aryl Propionic Acid Derivatives (en Inglés)"

The book emphasizes the methods that chemists use to conduct their research and design the new series of 3,3-diphenyl propionic acid derivatives were synthesized The key intermediate 3,3-diphenylpropionyl chloride was synthesized by the reaction of 3,3-diphenyl propionic acid and thionyl chloride. The intermediate was further subjected to reaction with various aromatic secondary amines in the presence of NaOH in acetone. After synthesis of compounds, the synthesized compounds were characterized by their IR, 1HNMR, Mass spectral data, and elemental analysis. These derivatives were screened for their analgesic activity (Hot plate and tail flick method) and anti-inflammatory activity (Carrageen induced rat paw edema method) by using Diclofenac sodium and Indomethacin as standard drugs, respectively. The compounds AK-5 and AK-3 exhibited significantly potent anti-inflammatory and analgesic activity (two to three times) when a comparison was made with the control group. The response of promising compound (AK-5) for analgesic and anti-inflammatory action was highest among all the test compounds and was almost similar to the standard compounds (Indomethacin and Diclofenac Sodium).