Libro Protein Homology Detection Through Alignment of Markov Random Fields: Using Mrfalign (Springerbriefs De Jinbo Xu; Sheng Wang; Jianzhu Ma

portada Protein Homology Detection Through Alignment of Markov Random Fields: Using Mrfalign (Springerbriefs in Computer Science)

Formato

Libro Físico

Editorial

Springer

Autor

Jinbo Xu; Sheng Wang; Jianzhu Ma

Año

2015

Idioma

Inglés

N° páginas

Encuadernación

Tapa Blanda

ISBN13

9783319149134

N° edición

2015

Categorías

Ciencias de la computación

Protein Homology Detection Through Alignment of Markov Random Fields: Using Mrfalign (Springerbriefs in Computer Science)

Jinbo Xu; Sheng Wang; Jianzhu Ma (Autor) · Springer · Tapa Blanda

Sin Stock

Reseña del libro "Protein Homology Detection Through Alignment of Markov Random Fields: Using Mrfalign (Springerbriefs in Computer Science)"

This work covers sequence-based protein homology detection, a fundamental and challenging bioinformatics problem with a variety of real-world applications. The text first surveys a few popular homology detection methods, such as Position-Specific Scoring Matrix (PSSM) and Hidden Markov Model (HMM) based methods, and then describes a novel Markov Random Fields (MRF) based method developed by the authors. MRF-based methods are much more sensitive than HMM- and PSSM-based methods for remote homolog detection and fold recognition, as MRFs can model long-range residue-residue interaction. The text also describes the installation, usage and result interpretation of programs implementing the MRF-based method.