Libro Modeling of Kinases Inhibitors: 3D-QSAR, Moecular Docking and ADMET De Aouidate, Adnane ; Aouidate, Mustapha

portada Modeling of Kinases Inhibitors: 3D-QSAR, Moecular Docking and ADMET

Formato

Libro Físico

Autor

Adnane Aouidate

Mustapha Aouidate

Editorial

Noor Publishing

Idioma

Inglés

N° páginas

144

Encuadernación

Tapa Blanda

Dimensiones

22.9 x 15.2 x 0.9 cm

Peso

0.22 kg.

ISBN13

9786202789363

Categorías

Gestión empresarial

Modeling of Kinases Inhibitors: 3D-QSAR, Moecular Docking and ADMET

Adnane Aouidate (Autor) · Mustapha Aouidate (Autor) · Noor Publishing · Tapa Blanda

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Reseña del libro "Modeling of Kinases Inhibitors: 3D-QSAR, Moecular Docking and ADMET"

The human kinome contains 518 proteins. They share a common mechanism of protein phosphorylation known to play an important role in cellular signaling pathways. Impaired kinase function is recognized to be involved in severe diseases like cancer. The challenge of this PhD work is the in silico identification of potentially interesting molecules concerning the inhibitory process of a set of protein kinases, namely PIM1, PIM2, CDC7, DRAK2 and CAMKIIδ. The faculty of this protein to interact in differentiation, proliferation and tissue repair phenomena makes their inhibitions crucial for treatments against tumor development in which they are involved. Despites their interests, until now there is no molecule acting on theses kinases has been proven by the Food and Drug Administration. In this way, the authors will focus, in this book on several in silico methods for rational drug design of new kinases inhibitors.